个人简介

  陈于平，副研究员，硕士生导师，省部级青年人才。2012年毕业于中国农业大学生命科学理科试验班，2018年于美国纽约州立大学石溪分校获得遗传学博士学位，在斯坦福大学医学院完成博士后训练。主要研究方向：以非洲爪蟾卵提取物、酵母为模型结合哺乳动物细胞探究1)生物大分子浓度和细胞周期的协同作用；2)细胞尺寸控制机制；3)胞质物理性质(粘度、拥挤度、酸碱度)对细胞生理的影响及其稳态成因。发现多基因差异表达决定真核细胞的稳态尺寸；蛋白质翻译过程在胞内属于扩散受限反应；蛋白质翻译和降解对胞质粘度的差异性响应可能导致自发的蛋白质浓度稳态。发表论文8篇。

  学习经历：

  2012/8-2018/12 纽约州立大学石溪分校遗传学 博士

  2008/9 2012/6 中国农业大学生命科学理科试验班 本科

  工作经历:

  2019/3-2024-5 斯坦福大学 博士后

  2012/8-2018/12 纽约州立大学石溪分校 研究助理

  生物大分子浓度和细胞尺寸控制。

  代表性文章

  (1) Yuping Chen; Jo-Hsi Huang; Connie Phong; James E. Ferrell ; Viscosity-dependent control of protein synthesis and degradation, Nature Communications, 2024, 15(1): 2149 (期刊论文)

  (2) Yuping Chen; Gang Zhao; Jakub Zahumensky; Sangeet Honey; Bruce Futcher ; Differential

  scaling of gene expression with cell size may explain size control in budding yeast, Molecular cell, 2020, 78(2): 359-370. e6 (期刊论文)

  (3) Yuping Chen; Bruce Futcher ; Scaling gene expression for cell size control and senescence in Saccharomyces cerevisiae, Current genetics, 2021, 67(1): 41-47 (期刊论文)

  (4) Yuping Chen; James E. Ferrell ; C. elegans colony formation as a condensation phenomenon, Nature communications, 2021, 12(1): 1-10 (期刊论文)

  (5) Jo-Hsi Huang; Yuping Chen; William YC Huang; Saman Tabatabaee; James E Ferrell Jr ;

  Robust trigger wave speed in Xenopus cytoplasmic extracts, bioRxiv., 2023 (期刊论文)

  学术成就

  (1) Yuping Chen ; Viscosity-dependent Control of Protein Synthesis and Degradation, Cell Size and Growth Seminar Series, Palo Alto, California, 2024-03-05至2024-03-05 (会议报告)

  (2) Yuping Chen; Jo-Hsi Huang; Connie Phong; James Ferrell ; Diffusion-dependent control of protein synthesis and degradation maintains cytoplasmic concentration, Physics of Life Symposium,San Francisco, California, 2023-10-12至2023-10-12 (会议报告)

  (3) Yuping Chen; Jo-Hsi Huang; Connie Phong; James Ferrell ; Diffusion-dependent control of protein synthesis and degradation maintains cytoplasmic concentration, qBio, Shenzhen, 2023-07- 29至2023-08-01 (会议报告)

  (4) Yuping Chen; Jo-Hsi Huang; Connie Phong; James Ferrell ; Diffusion-dependent Control of Protein Synthesis and Degradation Maintains Cytoplasmic Concentration, Cell Cycle Meeting, Salk Institute for Biological Studies, La Jolla, California, 2023-07-24至2023-07-27 (会议报告)

  (5) Yuping Chen; James Ferrell ; Diffusivity may affect cell cycle and translation, Cell Size & Growth Seminar Series, Palo Alto, California, 2021-04-27至2021-04-27 (会议报告)

  (6) Yuping Chen ; Speed, Direction, Mitosis, Lake Tahoe Meeting on Cell size and Cell Cycle Control, Lake Tahoe, California, 2020-01-21至2020-01-24 (会议报告)

  (7) Yuping Chen; Bruce Futcher ; Expression of Cell Cycle Activators Scales with Cell Size in Yeast, Cell Cycle Meeting, Salk Institute for Biological Studies, 2018-06-26至2018-06-29 (会议报告)

  (8) Yuping Chen; Gang Zhao; Bruce Futcher ; Classical yeast cell size mutants nevertheless retain good size homeostasis, The Cell Cycle Meeting, Cold Spring Harbor Laboratory, 2016-05-17至2016-05-21 (会议报告)